Impact of Anti-Dementia Medication on the Risk of Death and Causes of Death in Alzheimer’s Disease

Published 15.10.2019

Abstract

Background

The Finnish population offers many advantages for evaluating the impact of anti-dementia medication on mortality in Alzheimer's disease (AD) due to broad range of individual-level data collected in national health and social care registries and the fact that Finland has one of the highest mortality rates for dementia globally.

Objective

The aim of this study was to investigate the association of anti-dementia medication with 2-year risk of death and all-cause mortality in patients with AD.

Methods

This was a retrospective, non-interventional registry study based on individual-level data using Finnish national health and social care registries. An incident cohort of 9,204 AD patients (first AD diagnosis in 2012) was formed from a population of 316,470 individuals ≥74 years of age. The main outcome measure was overall 2-year risk of death. Statistical modelling was used to assess mortality (Kaplan-Meier) and adjusted hazard ratios (HR) (Cox proportional hazard model).

Results

Early start of anti-dementia medication (treatment started ≤3 months from AD diagnosis) reduced significantly the risk of all-cause death compared to AD patients who had late medication initiation (defined as treatment started >3 months from AD diagnosis/no medication; HR, 0.51; 95% confidence interval (CI), 0.46-0.57). Dementia was the most common recorded cause of death in both groups.

Conclusion

This study places importance on early diagnosis of AD and subsequent early initiation of drug treatment in decreasing 2-year risk of death.

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Authors

Miika Linna, Sauli Vuoti, Katariina Silander, Iiris Hörhammer, Olli Halminen, Teija Mikkola, Päivi Koivuranta-Vaara, Lauri J Virta, Mirkka Koivusalo, Tero Ylisaukko-Oja

Additional Information

Peer-Reviewed: yes.
Open Access: no.
Cite as: Linna, M., Vuoti, S., Silander, K., Hörhammer, I., Halminen, O., Mikkola, T., Koivuranta-Vaara, P., Virta, L. J., Koivusalo, M., & Ylisaukko-Oja, T. (2019). Impact of Anti-Dementia Medication on the Risk of Death and Causes of Death in Alzheimer's Disease. Journal of Alzheimer's disease : JAD, 71(4), 1297–1308. https://doi.org/10.3233/JAD-190288